Zymeworks

Research Associate II/Senior Research Associate, Assay Development

Discovery Research - Vancouver, BC

Description

Zymeworks is a clinical-stage biopharmaceutical company dedicated to the discovery, development and commercialization of next-generation bispecific and multifunctional biotherapeutics, initially focused on the treatment of cancer. Zymeworks’ suite of complementary therapeutic platforms and its fully-integrated drug development engine provide the flexibility and compatibility to precisely engineer and develop highly-differentiated product candidates.

About the Position

This position will report to a Bioassay Development Scientist within the Assay Development Group in the Discovery Research Department and will be based in Vancouver, BC.

Key Responsibilities:

• Performs advanced experiments following established methods.
• Applies knowledge of scientific methodologies, techniques, processes and procedures in conducting more technically demanding analyses. Troubleshoots methods and suggests novel and impactful changes to methods.
• Plans out next set of experiments to be performed in order to properly advance program.
• Documents raw and analyzed data. Independently interprets results and presents to team.
• Prepares written reports and analysis of complex experiments.
• May provide advanced technical guidance.
• Reviews work of team members for thoroughness and completeness.
• Seeks to understand ongoing projects through extensive attention to scientific literature and internally generated data.
• Assists in maintaining a clean, neat, organized and operational lab.
• Conducts all activities in accordance with scientific standards, OH&S regulations and established policies and practices.
• May co-author or author scientific papers.
• Actively works to foster an environment of effective and collaborative working relationships amongst employees, management and external partners.

Qualifications and Education

• RA II: Requires a BSc in a scientific discipline and a minimum of 3 to 5 years related experience (may include MSc) or an equivalent combination of education and experience.
• SRA: Requires a BSc in a scientific discipline and a minimum of 5 to 8 years related experience (may include MSc) or an equivalent combination of education and experience.
• Proven interpersonal skills with the ability to work collaboratively as a member of cross-functional team. Ability to establish and maintain effective working relationships.
• Good organizational skills and the ability to work effectively in a high paced, fast changing environment. Results-oriented.
• Critical observation skills and strong statistical analysis capability.
• Excellent oral, presentation and scientific/technical writing skills.
• Advanced knowledge and proficiency in performing lab techniques and methods which may include:
• ELISA
• Electrochemiluminescence (Mesoscale MSD)
• Homogeneous time-resolved fluorescence (HTRF) immunoassays
• Flow cytometry
• Protein purification
• Mammalian tissue culture
• Media and buffer preparation
• Preparation of serial dilutions
• Transient transfections of mammalian cell lines
• Antibody drug conjugate assays
• Reporter Gene Assays (luciferase, colourimetric)
• Second messenger assays
• Primary human immune cell isolation/depletion, expansion & culture (PBMCs, T cells, monocytes, macrophages, cDCs, pDCs)
• Mouse husbandry, handling, and humane treatment
• Mouse reagent administrations (i.p., s.c., and i.v.)
• Mouse necropsy and tissue collection to support oncology and immunology disease models
• Mouse primary immune cell isolation and culture
• Advanced knowledge and proficiency in the use of standard or specialized lab equipment which may include:
• Multimode microplate readers
• Flow Cytometers
• High content imaging devices
• Mesoscale MSD
• Laboratory Automation (Lynx, Hamilton)

Why Work for Us?

Innovation. Act with Integrity. Collaboration. Care

We come from many countries, cultures, races, ethnicities, abilities and nationalities. We bring our passions including singing, biking, swimming, dancing, cooking, volunteering, parenting, coaching and much more! We are proud of our nearly equal balance of men and women and strengthened by our non-binary and transgender team members. Every employee belongs.

We offer challenging career opportunities, competitive benefits and an environment that recognizes and rewards performance.

How to Apply

NOTE TO EMPLOYMENT AGENCIES: Zymeworks values our relationships with our Recruitment Partners. We will only accept resumes from those partners whom have been contracted by a member of our Human Resources team to collaborate with us. Zymeworks is not responsible for any fees related to resumes that are unsolicited or are received without contract.

Zymeworks

Zymeworks is an Equal Opportunity Employer

Submitted: 12/02/2020